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Coagulation Factor XIIIA (F13A1): Novel Perspectives in Treatment and Pharmacogenetics.
Gemmati D, Vigliano M, Burini F, Mari R, El Mohsein HH, Parmeggiani F, Serino ML. Gemmati D, et al. Curr Pharm Des. 2016;22(11):1449-59. doi: 10.2174/1381612822666151210122954. Curr Pharm Des. 2016. PMID: 26654441 Review.
Another important recently discovered function ascribed to FXIII is its ability to limit bacterial spreading from the lesion by incorporating specific macromolecules addressed to cellular infiltration, favouring in turn cell migration and survival, as observed also in fibrin-h …
Another important recently discovered function ascribed to FXIII is its ability to limit bacterial spreading from the lesion by incorporatin …
F13A1 Gene Variant (V34L) and Residual Circulating FXIIIA Levels Predict Short- and Long-Term Mortality in Acute Myocardial Infarction after Coronary Angioplasty.
Ansani L, Marchesini J, Pestelli G, Luisi GA, Scillitani G, Longo G, Milani D, Serino ML, Tisato V, Gemmati D. Ansani L, et al. Int J Mol Sci. 2018 Sep 14;19(9):2766. doi: 10.3390/ijms19092766. Int J Mol Sci. 2018. PMID: 30223472 Free PMC article.
Conversely, FXIIIA levels stratified by V34L predicted MACE at a lesser extent among L34-carriers (Hazard Risk (HR)(VV34) = 3.89, 2.19-6.87, p = 0.000003; HR(L34-carriers) = 2.78, 1.39-5.57, p = 0.0039), and V34L did not predict all MACE, only multiple-MACE occurrence (p = 0.0087 …
Conversely, FXIIIA levels stratified by V34L predicted MACE at a lesser extent among L34-carriers (Hazard Risk (HR)(VV34) = 3.89, 2.19-6.87, …
Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency.
Griffin KJ, Newell LM, Simpson KR, Beckers CML, Drinkhill MJ, Standeven KF, Cheah LT, Iismaa SE, Grant PJ, Jackson CL, Pease RJ. Griffin KJ, et al. Atherosclerosis. 2020 Feb;294:1-9. doi: 10.1016/j.atherosclerosis.2019.12.013. Epub 2019 Dec 17. Atherosclerosis. 2020. PMID: 31874419 Free PMC article.
RESULTS: No difference was found in the density of buried fibrous caps within brachiocephalic plaques from mice expressing or lacking these transglutaminases. Cardiac fibrosis developed in both Apoe/F13a1 double knockout and F13a1 single knockout mice, but not in Tg …
RESULTS: No difference was found in the density of buried fibrous caps within brachiocephalic plaques from mice expressing or lacking these …
Xueshuan Xinmaining Tablet Treats Blood Stasis through Regulating the Expression of F13a1, Car1, and Tbxa2r.
Zhang X, Zhang C, Sai J, Li F, Liu J, Li Y, Wang F. Zhang X, et al. Evid Based Complement Alternat Med. 2015;2015:704390. doi: 10.1155/2015/704390. Epub 2015 Mar 2. Evid Based Complement Alternat Med. 2015. PMID: 25821496 Free PMC article.
Xueshuan Xinmaining Tablet (XXT), the Chinese formula, has long been administered in clinical practice for the treatment of cerebral thrombosis and coronary heart disease. In this study, we aimed to study the effect and the molecular mechanism of activating blood circulati …
Xueshuan Xinmaining Tablet (XXT), the Chinese formula, has long been administered in clinical practice for the treatment of cerebral thrombo …
Efficacy and Mechanism of Buyang Huanwu Decoction in Patients With Ischemic Heart Failure: A Randomized, Double-Blind, Placebo-Controlled Trial Combined With Proteomic Analysis.
Zhu M, Wei J, Li Y, Wang Y, Ren J, Li B, Ma B, Wang X, Qiao L, Zhou C, Liu J. Zhu M, et al. Front Pharmacol. 2022 Mar 18;13:831208. doi: 10.3389/fphar.2022.831208. eCollection 2022. Front Pharmacol. 2022. PMID: 35370712 Free PMC article.
Objective: Buyang Huanwu Decoction (BYHW), a famous herbal prescription in traditional Chinese medicine (TCM), has been used for 200 years for treating ischemic heart failure (IHF). This study aims to assess the efficacy and safety of BYHW combined with guideline-guided ph …
Objective: Buyang Huanwu Decoction (BYHW), a famous herbal prescription in traditional Chinese medicine (TCM), has been used for 200 years f …
Transglutaminase 2 moderates the expansion of mouse abdominal aortic aneurysms.
Griffin KJ, Simpson KR, Beckers CML, Newell LM, Cheah LT, Yuldasheva NY, Iismaa S, Jackson CL, Scott JDA, Pease RJ. Griffin KJ, et al. JVS Vasc Sci. 2021 May 18;2:95-109. doi: 10.1016/j.jvssci.2021.04.002. eCollection 2021. JVS Vasc Sci. 2021. PMID: 34617062 Free PMC article.
Surprisingly, Tgm2 (-/-) /F13a1 (-/-) double knockout mice showed a trend toward decreased dilatation of the aorta 6 weeks after injury, and this finding was replicated in Tgm2 (-/-) /F13a1 (-/-) mice subjected to carotid artery injury. ...CONCLUSIONS: Knockout of T …
Surprisingly, Tgm2 (-/-) /F13a1 (-/-) double knockout mice showed a trend toward decreased dilatation of the aorta 6 weeks after inju …
Dysfunctional Network and Mutation Genes of Hypertrophic Cardiomyopathy.
Cui Y, Liu C, Luo J, Liang J. Cui Y, et al. J Healthc Eng. 2022 Jan 28;2022:8680178. doi: 10.1155/2022/8680178. eCollection 2022. J Healthc Eng. 2022. PMID: 35126952 Free PMC article.
RESULTS: In this study, 920 differentially expressed genes were obtained, and these genes were mainly related to metabolism-related signaling pathways. 187 interacting genes were identified by PPI network analysis, and the expression trends of C1QB, F13A1, CD163, FCN3, PLA …
RESULTS: In this study, 920 differentially expressed genes were obtained, and these genes were mainly related to metabolism-related signalin …
Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound Healing.
Alshehri FSM, Whyte CS, Mutch NJ. Alshehri FSM, et al. Int J Mol Sci. 2021 Mar 17;22(6):3055. doi: 10.3390/ijms22063055. Int J Mol Sci. 2021. PMID: 33802692 Free PMC article. Review.
A deficiency in FXIII manifests as a severe bleeding diathesis emphasising its crucial role in this pathway. The FXIII-A gene (F13A1) is expressed in cells of bone marrow and mesenchymal lineage. ...
A deficiency in FXIII manifests as a severe bleeding diathesis emphasising its crucial role in this pathway. The FXIII-A gene (F13A1) …
Let's cross-link: diverse functions of the promiscuous cellular transglutaminase factor XIII-A.
Mitchell JL, Mutch NJ. Mitchell JL, et al. J Thromb Haemost. 2019 Jan;17(1):19-30. doi: 10.1111/jth.14348. J Thromb Haemost. 2019. PMID: 30489000 Free article. Review.
Cells of bone marrow and mesenchymal lineage express the FXIII-A gene (F13A1) that encodes the cellular form of the transglutaminase, a homodimer of the A subunits, FXIII-A. ...In the last decade, emerging evidence has revealed that this diverse transglutaminase can be ext …
Cells of bone marrow and mesenchymal lineage express the FXIII-A gene (F13A1) that encodes the cellular form of the transglutaminase, …
The contribution of chronic intermittent hypoxia to OSAHS: From the perspective of serum extracellular microvesicle proteins.
Zhang H, Yang F, Guo Y, Wang L, Fang F, Wu H, Nie S, Wang Y, Fung ML, Huang Y, Deng H, Qin Y, Ma X, Wei Y. Zhang H, et al. Metabolism. 2018 Aug;85:97-108. doi: 10.1016/j.metabol.2018.02.012. Epub 2018 Mar 6. Metabolism. 2018. PMID: 29522771
By comparing the DEPs identified from the two models, 3 proteins (CRP and FN1 and F13a1) were found identical with the same alteration pattern (CRP was upregulated, FN1 and F13a1 were downregulated) in SEMVs from OSAHS patients and CIH rats, which were further verif …
By comparing the DEPs identified from the two models, 3 proteins (CRP and FN1 and F13a1) were found identical with the same alteratio …
22 results